A $6.3 billion Medline IPO, rising deal totals and looming tech listings are reshaping expectations for global markets.

Five members of the Illinois-based Mills family joined the three-comma club on Wednesday, as the nearly 60-year-old medical supplies giant that their fathers founded finally went public.

It set a new benchmark for Wall Street as the largest US IPO of 2025 and the biggest US stock debut in four years, since EV maker Rivian raised $11.9 billion in 2021. Medline also became the fifth U.S.-listed firm to raise more than $5 billion in an IPO over the past decade, according to Bloomberg.

The decades-old company, which makes everything from wheelchairs to scalpels, will debut on the Nasdaq after raising more than $6 billion.

Here are some of the major companies whose stocks moved on the week’s news.

Forget weight-loss drugs and the latest development for their makers — the hottest healthcare stock right now makes those ubiquitous striped blankets for newborns and offers more than 300,000 other medical and surgical products.

Medline shares surged in their trading debut Wednesday, after the medical supply company raised $6.26 billion in one of the biggest initial public offerings in recent years.

Medline Inc. (Nasdaq: MDLN) (“Medline”) announced today that it has closed its upsized initial public offering of 248,439,654 shares of its Class A common stock at a public offering price of $29.00 per share,