Head coach Kyle Shanahan of the San Francisco 49ers looks on during warmups before the game against the Arizona Cardinals at State Farm Stadium on Nov. 16, 2025 in Glendale, Ariz. A costly penalty by a San Francisco 49ers defensive player led head coach Kyle Shanahan to bench him and confront him on the sidelines.

The San Francisco 49ers are already without Fred Warner, and they may have lost another linebacker early against the Arizona Cardinals on Sunday.

Wide receiver Skyy Moore returned the opening kickoff 98 yards and running back Christian McCaffrey got the final yard the Niners needed for a touchdown one play later. That made it 7-0 with 16 seconds off the clock in Arizona.

The San Francisco 49ers face the Arizona Cardinals in Week 11 of the NFL season on Sunday at State Farm Stadium.

This guy Jaxon Smith-Njigba is something else! He leads the league in receiving yards and he shows just why with a sublime one-handed catch down the left sideline to clutch Sam Darnold's floated pass over the top of the defender.

The Arizona Cardinals play host to the San Francisco 49ers in Week 11 NFL action. Both teams move into this week hoping to rebound in a massive way

The San Francisco 49ers entered Sunday in Week 11 with a healthy team, at least in terms of players on the roster. Quarterback Brock Purdy and receiver Ricky Pearsall would return after missing several games.