Loss of function of multiple ALS-associated RNA-binding proteins leads to reduced UNC13A expression through two distinct mechanisms: TDP-43 loss causes cryptic exon inclusion and mRNA destabilization, ...

Amyotrophic Lateral Sclerosis (ALS), commonly known as Lou Gehrig’s disease, is a rare yet devastating neurological disorder that progressively weakens the body’s voluntary muscles. It occurs when ...

The exact genetic and epigenetic cause of the sporadic form of amyotrophic lateral sclerosis (ALS), which affects approximately 90% of patients, are largely unknown. Previous work found that ...