Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

Epithelial-to-mesenchymal transition (EMT) is one of the main causes of peritoneal fibrosis. However, the pathophysiological mechanisms of EMT, specifically its relationship with autophagy, are still ...

Spinal cord injury (SCI) can cause a range of functional impairments, and patients with SCI have limited potential for functional recovery. Previous studies have demonstrated that autophagy plays a ...

A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel therapeutic target. AD, a representative form of senile dementia, occurs ...

Autophagy—meaning "self-eating" in Greek—is a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out or dysfunctional components. Serving as an essential ...

Autophagy, the process by which cells recycle damaged components, has long been associated with neuroprotection. However, the precise mechanisms by which autophagy maintains brain health have remained ...

A complex cellular process called autophagy is the topic of a major new textbook which encapsulates over 30 years of research in this growing field of study. A complex cellular process called ...

Illustration of an autophagosome (light blue double-membrane to the right) engulfing cellular material. David S. Goodsell and Daniel Klionsky/RCSB PDB-101, CC BY-SA Don’t let the textbook diagram of a ...

Type 1 diabetes is widely understood as an autoimmune disease, with the immune system attacking the insulin-producing beta ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...