Motile eukaryotic cells such as Dictyostelium discoideum and human neutrophils extend pseudopodia with a typical 1-minute life cycle. In a uniform gradient of chemoattractant, these pseudopodia are ...

Chemotactic migration and invasion play an essential role in many normal and pathological processes including immune response, cell differentiation, and tumor metastasis. Methods to study factors that ...

Graft-versus-host disease (GVHD) is a major barrier to successful allogeneic hematopoietic stem-cell transplantation (HSCT). The chemokine receptor CCR5 appears to play a role in alloreactivity. We ...

Chemotaxis is a mechanism that provides directional cellular movement in response to alterations in the chemical composition of the immediate environment. The mechanism, in its simplest form, governs ...

To measure directional migration, the Transwell ® Boyden chamber has been widely regarded as the mainstay in vitro method. However, it is known for being technically tricky, hard to troubleshoot, and ...