The maintenance of genomic integrity in eukaryotic cells relies on the DNA damage checkpoint, a sophisticated signalling pathway that detects DNA lesions, transduces signals via sensor kinases and ...

The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase is a master regulator of the cellular response to replication stress and DNA damage. ATR detects stretches of single-stranded DNA coated ...

Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team at the University of Würzburg has now gained new insights into the DNA ...

A research team has successfully identified a novel DNA damage repair pathway in human cells. This study is the first to discover that proteins present in the nuclear membrane of cells directly ...

Researchers have uncovered answers that provide the detail to explain two specific DNA repair processes that have long been in question. Researchers from the University of Birmingham have uncovered ...

Migrating newborn neurons suffer routine double-strand DNA breaks from physical stress during brain development.

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Drawing inspiration from natural cell signaling cascades, chemists at Université de Montréal (UdeM) have developed a DNA-based signaling cascade that allows them to quantify and report via an easily ...

The Korea Research Institute of Standards and Science has developed an ultrasensitive immunoassay-based analytical platform ...

Its origin from mitochondrial DNA suggests that it may function as part of a retrograde signaling system, where mitochondria ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...