The initiation of DNA replication in eukaryotic cells begins with the assembly of pre-replicative complexes (pre-RCs) at many sites along each chromosome during the G1 phase of the cell cycle. Pre-RCs ...
In prokaryotes, DNA replication initiates at a single defined origin and proceeds bidirectionally via a multiprotein replisome that unwinds the duplex and synthesises new strands. Elongation is ...
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