Nature

d-Asb11 is an essential mediator of canonical Delta–Notch signalling

Thus, the present study has shown that d-Asb11 is a positive regulator of Notch signalling, probably acting at the level of DeltaA ubiquitylation and thereby regulating Notch signalling activity in a ...
JSTOR Daily

Delta/Notch signaling in glia maintains motor nerve barrier function and synaptic transmission by controlling matrix metalloproteinase expression

While the role of barrier function in establishing a protective, nutrient-rich, and ionically balanced environment for neurons has been appreciated for some time, little is known about how signaling ...
ALZFORUM

γ-Secretase Cuts Not Just Notch, but Ligands Delta and Jagged, Too

A report in the January 24 online Journal of Biological Chemistry indicates that the Notch ligands Delta and Jagged are also substrates for γ-secretase, the intramembrane aspartyl protease responsible ...
Science Daily

Scientists uncover a new role for blood-brain barrier in neuron function and damage

Researchers have made a surprising discovery linking Delta/Notch signaling in subperineurial glia (SPG) to the regulation of nerve ensheathment and neurotransmitter release at the Drosophila ...
Nature

On the mechanisms of epidermal stemness and differentiation

High Wnt and low Notch activities characterize epidermal stem cells (SCs), while low Wnt and high Notch activities characterize the terminally differentiated epidermal cells (TDCs). However, the ...