The peripheral endoplasmic reticulum (ER) forms a continuous, dynamic network of tubules that plays an important role in protein transport and quality control, cellular signaling, and stress response.

N-methyl-D-aspartate receptors (NMDARs) are excitatory neurotransmitter-gated ion channels in the mammalian central nervous system and play a key role in mediating synaptic plasticity and maintaining ...

DJ-1 is a protein with wide subcellular distribution and pleiotropic functions. The loss-of-function mutations of DJ-1 are associated with autosomal recessive early-onset Parkinson's disease yet the ...

Desmosomes and keratin are now found to regulate the distribution and dynamics of the endoplasmic reticulum (ER). This suggests that a range of ER functions may be coordinated by this intercellular ...

A new review in Cold Spring Harbor Perspectives in Biology from the Lippincott-Schwartz Lab at HHMI's Janelia Research Campus examines the diverse endoplasmic reticulum structures that have been ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed -- for instance in ...

The endoplasmic reticulum is usually the biggest organelle in eukaryotic cells; it has various portions that serve different purposes; and it is the site of protein production, as well other other ...

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What is the endoplasmic reticulum? The endoplasmic reticulum is the single largest membrane-bound organelle found inside eukaryotic cells. Its complex structure containing tubules, sheets, and ...