Congenital heart defects are the most common form of human birth defect, but we still don't fully understand what causes them. Previous research had suggested that some heart defects could be ...

Congenital heart defects are the most common form of human birth defect, but we still don't fully understand what causes them. Previous research had suggested that some heart defects could be ...

New research in Sweden has produced a "blueprint" revealing how the human heart is built during prenatal development. It offers insights that could lead to improved prenatal care and new treatments ...

Improvements in treatment and survival of neonates with complex congenital heart disease have led to growing recognition of the associated neurodevelopmental impairments. In this review, we explore ...

Newborns with a heart defect may have two strikes against their future health, rather than one. Babies with heart birth defects appear to have a higher risk of developing childhood cancer, compared to ...

New research in Sweden has produced a "blueprint" revealing how the human heart is built during prenatal development. It offers insights that could lead to improved prenatal care and new treatments ...

One to two out of every 100 newborn babies are born with a Congenital Heart Defect (CHD), yet the exact cause remains unclear. Human geneticists at the University Medicine Oldenburg (Germany) have now ...

Shabnam Peyvandi, MD, MAS (right), is a pediatric cardiologist at UCSF Benioff Children’s Hospitals and senior author of the study that found that babies who did not respond to increased oxygen and ...

Phosphodiesterase 2A (Pde2A) hydrolyzes both cyclic nucleotides (cAMP and cGMP) and is activated by cGMP. Knockout mouse models for the different PDE isoforms have been generated (Supplementary Table ...

An advanced human heart organoid system can be used to model embryonic heart development under pregestational diabetes-like conditions, researchers report. The organoids recapitulate hallmarks of ...

How did your heart form? What triggered your first heartbeat? To this day, the mechanisms of human heart development remain elusive. Researchers know the heart is the first organ to fully function in ...