Histone post-translational modifications (PTMs) comprise one of the most intricate nuclear signaling networks that govern gene expression in a long-term and dynamic fashion. These PTMs are considered ...

The histone code hypothesis posits that distinct combinations of histone modifications can recruit chromatin-modifying enzymes and exert epigenetic control over heterochromatin assembly. In the March ...

The DNA in our cells is wrapped around proteins to help compact it enough to fit. Chemical modifications on those proteins—known as histones—help regulate various processes, such as transcription.

Histones are perhaps more intimately linked with DNA than any other protein. Transcriptional regulation, recombination, repair, and replication--basically anything that happens to the DNA--must happen ...

Plant homeodomain (PHD) finger proteins are involved in various developmental processes and stress responses. They recognize and bind to epigenetically modified histone H3 tail and function as histone ...

Many DNA repair proteins have additional functions other than their roles in DNA repair. In addition to catalyzing PCNA polyubiquitylation in response to the stalling of DNA replication, SHPRH has the ...

(Philadelphia, PA) - Rearrangements of the mixed lineage leukemia gene, MLL, are associated with aggressive leukemias in both children and adults. Researchers at the University of Pennsylvania School ...

Dr. Terry Orr-Weaver and colleagues (MIT & Nagasaki University School of Medicine) present the first genetic analysis of the recently identified nucleosomal histone kinase, NHK-1. The authors ...

1 Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA 2 Department of Chemistry, Princeton University, Princeton, NJ 08544, USA Histone post-translational modifications ...

Strands of DNA wrapped around a histone. Credit: Molekuul/Science Source Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes ...