A pair of copper catalysts can create chiral amides in a new, light-driven process, offering a useful alternative to the standard method for making these staples of medicinal chemistry (Nature 2021, ...
Figure 1: Comparison of native and sulphenyl-amide PTP1B. A crystallographic soaking experiment with 2-phenyl-isoxazolidine-3,5-dione, one of the identified PTP1B inhibitors, detected unexpected ...
On first appearances, 2-quinuclidone is a small, uncomplicated molecule compared with the many complex systems made by organic chemists in recent years. Yet the synthesis of this compound by Tani and ...
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