Zellweger syndrome was first reported in 1964 as an autosomal recessive disease with multiple congenital malformations. 8 Patients with ZS manifest severe hypotonia from the neonatal period, ...

The cell organelles known as 'peroxisomes' dispose toxic substances and fats in the human body, among other things, and, in doing so, they prevent serious illnesses. The 'Pex' group of proteins ...

Peroxisomal biogenesis disorder, which has been linked only to lipid metabolism, is also associated with sugar metabolism. Meeting a young patient with Zellweger syndrome, a rare, life-threatening ...

Zellweger spectrum disorders (ZSDs) are a group of rare genetic diseases marked by a lack of functional peroxisomes caused by mutations in various PEX genes. Zellweger spectrum diseases are a subset ...

A fundamental question in cell biology is: how do cells get rid of waste? Every living cell continuously generates metabolic by-products, damaged macromolecules and potentially toxic compounds that ...

Scientists at Münster University used cryogenic electron microscopy to study the atomic-level processes of peroxisomal AAA-ATPase complex Pex1/Pex6, crucial for detoxification and fat metabolism in ...

Researchers at the University of Exeter say they have discovered how the movement and membrane dynamics of peroxisomes are mediated. These organelles fulfill critical protective functions in the cell ...

Every system has its waste disposal system. The cell organelles known as “peroxisomes” dispose toxic substances and fats in the human body, among other things, and, in doing so, they prevent serious ...