Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 27 (July 7, 2020), pp. 15609-15619 (11 pages) Ribosome biogenesis is a complex process, and dozens of ...

The discovery of ribosomes dates back to the 1950s, when George Palade first observed dense particles in the cytoplasm of cells using electron microscopy. These particles were later named "ribosomes" ...

In mammalian cells, the nucleolus is the central site for ribosome biogenesis. It is composed of distinct subcompartments: the fibrillar center (FC), the dense fibrillar component (DFC), the periphery ...

Ribosomal RNA (rRNA) is a type of molecule and a key building block of the ribosome, the cell's protein-making machinery. rRNA accounts for much of the RNA in a cell, and it's crucial for life. It's ...

Ribosomes carry out the cell’s most essential function—translating genetic information into proteins. But even though scientists understand much about how these protein generators are formed, their ...

Antibiotic-driven modifications to ribosomal RNA (rRNA) have been suspected of giving rise to antibiotic resistance. For example, antibiotics can alter methylation patterns in rRNA, changing rRNA ...

Hyperthermophilic archaea are true survival experts. They thrive in boiling hot springs and deep-sea vents—environments lethal to nearly all other forms of life. Researchers at the German Archaea ...

In the 1940s, scientists at the recently established National Cancer Institute were trying to breed mice that could inform our understanding of cancer, either because they predictably developed ...

A single iron-sulfur building block directly determines whether ribosomes—the protein factories of our cells—work smoothly or not. This is the conclusion of a recent research project led by the RPTU ...