How large, fully folded proteins can pass through cell membranes without destroying them has long been one of the open questions in cell biology. Using cryo-electron microscopy (cryo-EM), Leonid ...

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which ...

The scanning electron microscope (SEM) delivers high resolution, high depth of field, and an image quality as if microscopic objects are seen by the naked eye. This makes it not only a powerful ...

Fifteen years ago, physicists worked out a method to increase image contrast by hitting the electron imaging beam with an ...

Understanding the mechanistic interplay between antibodies and invading pathogens is essential for vaccine development. Current methods are labour and time intensive and limited by sample preparation ...

Electron microscopy is a powerful technique that provides high-resolution images by focusing a beam of electrons to reveal fine structural details in biological and material specimens. 2 Because ...

In a basement lab in Brandeis' Rosenstiel building, a refrigerator-sized microscope dominates a small, windowless room. On its surface, it looks like a featureless white box. Yet inside, it's a study ...

Imagine owning a camera so powerful it can take freeze-frame photographs of a moving electron—an object traveling so fast it could circle the Earth many times in a matter of a second. Researchers at ...

They can image a wide range of materials and biological samples with high magnification, resolution, and depth of field, thereby revealing surface structure and chemical composition. Industries like ...

Traditional electron microscopy techniques include scanning electron microscopy (SEM) and transmission electron microscopy (TEM), where electrons that interact with the sample are imaged. 4 The ...

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