Head coach Kyle Shanahan of the San Francisco 49ers looks on during warmups before the game against the Arizona Cardinals at State Farm Stadium on Nov. 16, 2025 in Glendale, Ariz. A costly penalty by a San Francisco 49ers defensive player led head coach Kyle Shanahan to bench him and confront him on the sidelines.

The San Francisco 49ers entered Sunday in Week 11 with a healthy team, at least in terms of players on the roster. Quarterback Brock Purdy and receiver Ricky Pearsall would return after missing several games.

Sunday marks the start of a crucial stretch of games for the San Francisco 49ers, who will visit the Arizona Cardinals to begin that four-game journey. The 49ers are in Arizona before hosting the Carolina Panthers,

Can the Arizona Cardinals upset the 49ers in Week 11? Explore the keys to victory, including Michael Wilson stepping up, Cody Simon’s defensive leadership, and Jonathan Gannon’s aggressive game plan.

What's the Arizona Cardinals vs San Francisco 49ers score? Follow our live score updates for latest news, highlights, analysis from NFL Week 11 game.

Brock Purdy hit George Kittle for 30-yard TD, extending the San Francisco 49ers lead over the Arizona Cardinals.

Oct 6, 2024; Santa Clara, California, USA; San Francisco 49ers tight end George Kittle (85) gestures after a catch against the Arizona Cardinals during the fourth quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images / Darren Yamashita-Imagn Images

The San Francisco 49ers (6-4) visit the Arizona Cardinals (3-6) Sunday in Week 11. Kickoff from State Farm Stadium in Glendale, Arizona, is at 4:05 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Cardinals odds and make our expert NFL picks and predictions for the best bets.

Preview the San Francisco 49ers' NFL Week 11 matchup with the Cardinals, including live stream, TV channel, odds, and game information.

The Cardinals' Week 11 game against the 49ers will basically only get coverage in the two teams' home viewing markets.

The 49ers head to State Farm Stadium to face the Arizona Cardinals with Brock Purdy back under center. Purdy was cleared off the injury report and is starting after missing six games with a turf-toe variant.

The San Francisco 49ers and Arizona Cardinals will meet on Sunday at State Farm Stadium. Here's who experts think will win the Week 11 battle.