A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive ...
A research team has developed a way to produce a subset of highly specialised brain neurons that centrally degenerate in motor neuron disease and are damaged in spinal cord injury, laying foundations ...
Trained immunity provides a unifying framework linking innate immune memory to both protective and maladaptive inflammation ...
Developmental electrophysiological adaptations and heat-sensitive proteins, such as TRPV3, in cortical excitatory neurons help maintain stable activity levels when brain temperature rises by 2–3°C ...
Proteomics experiments on Drosophila reveal sex-specific effects in aging, and an important role for a protein called DIP-β.
Identification of a nitric oxide-regulated transitional state of Müller glia reveals a key mechanism enabling neuronal regeneration in the injured vertebrate retina.
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