Jiang R, Zheng X, Sun J, Chen L, Xu G, Zhang R. Classification for Alzheimer's disease and frontotemporal dementia via resting-state electroencephalography-based coherence and convolutional neural ...

Blood tests for Alzheimer’s disease are rapidly transforming the way clinicians diagnose the disease. Still, some scientists urge caution when interpreting results, arguing that the meaning of a ...

Rarely do scientists discover a new pathogenic mutation for a sporadic disease. Even less often do they find one that explains half the cases. Pinning disease on a dinucleotide expansion? That’s a new ...

Contact Information Kellen Petersen, Ph.D. St. Louis, United States Professional Information InstructorWashington University in St. Louis https://kellenpetersen ...

Scientists continue to look for new ways to target sticky amyloid plaques in the brain. The approved immunotherapies have well-known limitations. In the March 5 Science, Marco Colonna and colleagues ...

Circular RNAs are the byproducts of aberrant “backsplicing.” They accumulate and cause problems in the brain with age. According to a study published March 5 in Molecular Cell, ribonuclease κ—an ...

Studies have confirmed the existence of neurogenesis in the adult human brain, but whether newborn neurons bolster cognitive abilities remains controversial. In the February 25 Nature, scientists led ...

Tau made in the brain eventually shows up in blood, but scientists still aren’t sure how it gets there. Now, research featured in Cell Press Blue offers a new idea. This journal launched in January to ...

The MCI-Park mice are compound mutant (Ndufs2fl/fl; DAT IREScre/+) animals in which Ndufs2, a gene encoding a core subunit of the mitochondrial respiratory chain, is selectively inactivated in ...

The gene PSEN2 encodes presenilin-2, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. Missense mutations in PSEN2 are a rare cause of early onset Alzheimer's disease.

The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...

Rember® is a purified, proprietary formulation of methylthioninium chloride (MTC), also known as methylene blue. This old drug predates the FDA. It is being widely used in Africa to treat malaria, as ...