The EMBO Journal1d
Trained immunity of intestinal tuft cells during infancy enhances host defense against enteroviral infections in mice
Our present study implies that intestinal tuft cells can be trained by IL-25 and it may explain the different susceptibility ...
The EMBO Journal3d
Gene therapy for epilepsy targeting neuropeptide Y and its Y2 receptor to dentate gyrus granule cells
Co-expressing NPY and its inhibitory receptor Y2 in excitatory hippocampal cells allows inhibitory autoregulation of ...
The EMBO Journal6d
Histamine synthesis and transport are coupled in axon terminals via a dual quality control system
Neurotransmitters are key for synaptic transmission at axon terminals, but their transport modalities remain debated. This ...
The EMBO Journal6d
HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43
HIV-1 Vpu triggers the cleavage of TDP-43 by stimulating Caspase 3 activation. The cleavage products generated can induce the ...
The EMBO Journal6d
Next generation of “magic bullets”, solutions from the microbial pangenome
These toxins provide new tools for precision cancer medicine, bringing us closer to the elusive “magic bullet.” In addition, ...
The EMBO Journal8d
An hepatitis B and D virus infection model using human pluripotent stem cell-derived hepatocytes
This study presents human pluripotent stem cell-derived hepatocyte-like cells (HLCs) as a culture system that expands the ...
The EMBO Journal2d
O-GlcNAcylation in the osteoblast lineage—boosting the complexity of Wnt-stimulated bone formation
Although differentiation and activity of bone-forming osteoblasts are regulated at various levels, there is ample evidence that components of the Wnt signaling pathway play a dominant role in bone ...
The EMBO Journal7h
FBXO38 is dispensable for PD-1 regulation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The ubiquitin ligase FBXO38 does not regulate ...
The EMBO Journal1d
Systematic mapping of mitochondrial calcium uniporter channel (MCUC)-mediated calcium signaling networks
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The mitochondrial calcium uniporter channel ...
The EMBO Journal2d
The global phosphorylation landscape of mouse oocytes during meiotic maturation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...
The EMBO Journal3d
Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-α/egr and ImpL2 signaling in Drosophila larvae
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...
The EMBO Journal2d
Terminal α1,2-fucosylation of glycosphingolipids by FUT1 is a key regulator in early cell-fate decisions
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The embryonic cell surface is rich in ...