The beloved royal died on March 1 from POLG Mitochondrial disease — a rare genetic disorder that affects approximately one in 5,000 people. The genetic disorder affects multiple organ systems and the mitochondria,

Luxembourg’s royal family are in mourning after the death of a young prince who had lived with a rare genetic condition. Prince Frederik died on March 1 2025 in Paris at the age of

Prince Frederik of Luxembourg, who died at 22, spoke about the rare genetic disorder he navigated in a video released by The PolG Foundation he founded.