Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

Parthenolide is a natural compound that has shown highly promising anticancer activity. Even though its mode of action has been studied for decades, its antimitotic activity has been largely ...

DNMT3A mutations may also have hitherto unrecognised non-canonical functions in HSCs. TP53 in humans, or Trp53 in mice (generally referred to as p53 throughout this text) is a key tumour suppressor ...

In patients affected by OXPHOS defects and a mouse model of mitochondrial myopathy, we find that a starvation‐like response promotes muscle protein breakdown and amino acid utilization to support ...

Author Correction: Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy ...

Spatial proteomics (SP) encompasses a diverse array of technologies that vary in scale, resolution, and sensitivity, offering researchers and clinicians a broad range of tools to investigate the ...

We integrate proteomics with patient-derived xenograft models to identify a personalized treatment for an adolescent with primary and metastatic spindle epithelial tumor with thymus-like elements ...

Correct mitotic spindle alignment is essential for tissue architecture and plays an important role in cell fate specification through asymmetric cell division. Spindle tethering factors such as ...

After the Covid-19 pandemic, pertussis has made a spectacular comeback in Europe and many other parts of the world, while during the pandemic it had essentially disappeared because of the social ...

We report here that radiation itself counterintuitively drives recurrence by inducing senescence of tumor cells. Mechanistically, the senescent tumor cells secrete senescence-associated secretory ...

We report apelin-specific cleavage and activation by Furin as a key player in colon cancer and early events of colon cancer and liver cells interaction leading to metastasis. Alteration of apelin ...

Many studies have used single-cell RNA sequencing (scRNA-seq) to infer gene regulatory networks (GRNs), which are crucial for understanding complex cellular regulation. However, the inherent noise and ...