The beloved royal died on March 1 from POLG Mitochondrial disease — a rare genetic disorder that affects approximately one in 5,000 people. The genetic disorder affects multiple organ systems and the mitochondria,

Prince Frederik of Luxembourg, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, has died after a lifelong battle with a rare genetic disorder known as POLG mitochondrial disease.

Prince Frederik of Luxembourg, who died at 22, spoke about the rare genetic disorder he navigated in a video released by The PolG Foundation he founded.