If the 49ers make the playoffs McCaffrey might start to feel the effects of the 400-plus touches he’s on pace for, but that’s a concern for down the road.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

As both teams jockey for position in the playoff standings, the San Francsico 49ers battle the Carolina Panthers on Monday Night Football today. Find out how to watch for free.

Sunday Night Football heads to the West Coast this week for a Falcons vs 49ers showdown. Live coverage begins at 7 PM ET on NBC and Peacock.

Everything you need to know about the NFL match between Cleveland Browns and San Francisco 49ers, as well as kick-off time and team news

Here we will look at and discuss some bold predictions for the game between the 49ers and the Browns in Week 13 of the 2025 NFL season.