The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

The San Francisco 49ers are facing an uphill battle in their quest to earn a playoff spot after suffering their second ...

San Francisco 49ers quarterback and Iowa State alum Brock Purdy is showing promising signs after being injured on Nov. 17.

But even if the 49ers had the trio of stars, the game’s result likely would have stayed the same (although the score likely ...

If defense wins championships, NFL quarterbacks win headlines—and a whole lot of blame when things go south. Week 12 gave us ...

Watch a Thanksgiving triple-header live on Sky Sports NFL from 5pm Thursday as the Detroit Lions face the Chicago Bears at ...

San Francisco quarterback Brock Purdy took part in some light throwing on Monday after missing his first career game because ...

Brandon Allen's first start with the 49ers didn't go so well. He made some nice throws, but he fumbled twice, threw an ...