The Los Angeles Rams' bitter rival suffered yet another devastating injury during their Week 13 road loss against the Buffalo ...

It doesn't seem like this is going to be the 49ers' year to get over the hump, but that doesn't mean that big changes are ...

San Francisco 49ers star Christian McCaffrey could "potentially" be lost for the season with a knee injury, head coach Kyle Shanahan said Sunday night.

The San Francisco 49ers' visit to Buffalo could be more painful than expected for Kyle Shanahan following the loss to the ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

Christian McCaffrey’s injury threatens to sideline the 49ers’ star running back for the rest of the season. The team’s ...

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs.

The 49ers season is still trending down and now they're searching for answers on if they can get back on track.

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...