Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from November 16, 2025 on ESPN.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

Jacoby Brissett completed an NFL-record 47 passes, but San Francisco's offense rolled in Purdy's first game in weeks.

Daryl Johnston and Kevin Kugler broke down the San Francisco 49ers massive win over the Arizona Cardinals in Brock Purdy's return.

49ers' Mac Jones expected to draw trade interest, according to NFL insider originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The San Francisco 49ers have been one of the more banged-up teams in the NFL. Brock Purdy, the $262 million starting quarterback, has missed most of the season.

The San Francisco 49ers entered Sunday in Week 11 with a healthy team, at least in terms of players on the roster. Quarterback Brock Purdy and receiver Ricky Pearsall would return after missing several games.

On the 'Chiefs Wire Podcast Interview Series', we showcase new players, celebrities, and prominent NFL players with unique takes and stories about the Kansas City Chiefs.

Rise of the 49ers premieres on Feb. 1 at 9 p.m. ET with back-to-back episodes on AMC. The final two episodes will debut on the network on Feb. 2 at 9 p.m. ET.