The Arizona Cardinals take on the San Francisco 49ers on Sunday at State Farm Stadium, kicking off at 4:05 p.m. ET (2:05 p.m. ET). The Cardinals are 3.5-point underdogs in this game. They are 1-6 in their last seven games and lost to the 49ers once already this season.

Can the Arizona Cardinals upset the 49ers in Week 11? Explore the keys to victory, including Michael Wilson stepping up, Cody Simon’s defensive leadership, and Jonathan Gannon’s aggressive game plan.

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49ers' Mac Jones expected to draw trade interest, according to NFL insider originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The San Francisco 49ers have been one of the more banged-up teams in the NFL. Brock Purdy, the $262 million starting quarterback, has missed most of the season.

The Niners are missing Nick Bosa, Fred Warner, Brandon Aiyuk, and seemingly countless others. The Cardinals will suit up without Marvin Harrison Jr. and Will Johnson. It sets this game up to be gritty and emotional, but both teams still have plenty of good players and Pro Bowl talents.

If you told anybody that the San Francisco 49ers would have a 6-4 record through nine games, even though Brock Purdy only played in two of those games, they likely would think you are crazy. However, that is how the 2025 campaign has unfolded for the ...

In a 34-24 victory over the New York Giants on Nov. 2, Robinson bowled over cornerback Deonte Banks on an 18-yard touchdown run. In a 42-26 loss to the Los Angeles Rams on Nov. 9, Robinson smashed through a tackle attempt by inside linebacker Nate Landman on a 1-yard touchdown run.