New study alert 🔬 🚨 On Nov 14, 2025 Esper et al. (a group out of 🇨🇦) published in Nature Communications that dystrophin loss in Duchenne muscular dystrophy (DMD) doesn’t just hit after birth — it actually disrupts muscle stem cell function during fetal (secondary) muscle devrlopment 🤰 They found fewer progenitors, smaller fibers, and mis-polarized cells in DMD mouse embryos 🐭 Even cooler: deleting AAK1 (a kinase) rescued that polarity and helped restore development ❗️ This reveals a fetal
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Dystrophin is a vital protein that plays a key role in stabilizing muscle fibers by linking the sarcomeres to the cell membrane, specifically the plasma membrane. It forms a protective link between the contractile elements inside the muscle cell and the external extracellular matrix, preventing muscle damage during contraction. As muscles contract and stretch, the mechanical stress exerted on the sarcomeres is transmitted across the membrane via dystrophin, which acts as a bridge, dispersing thi
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